Have we given up too much? On yielding climate representation to experts

Margaret McCartney: Have we given guidelines too much power?

“Guidelines, not tramlines,” said David Haslam, chair of the National Institute for Health and Care Excellence (NICE), at its conference this year. Amen to that, but for those of us in primary care, how well do guidelines fit our patients? Guidelines should be a good idea. It’s impossible to keep on top of all new research, to assess its relevance, outcomes, and biases, and to systematically re...

Have we given up on a cure for ovarian cancer?

In December 2014, on the force Web site, executive director Sue Friedman, heralded a game-changing holiday gift for people with BRCA mutations: “Today is a landmark for the hboc [hereditary breast and ovarian cancer] community” 1. In an accompanying article 2, Lisa Rezende wrote about the U.S. Food and Drug Administration (fda) decision to approve olaparib for the treatment of recurrent ovarian...

Are we spending too much on HIV?

Are We Consuming Too Much

I s humanity’s use of Earth’s resources endangering the economic possibilities open to our descendants? There is wide disagreement on the question. Many people worry about the growth in our use of natural resources over the past century. Some of this increase reflects the higher resource demands from a growing world population. But it also reflects the growth of per capita output and consumptio...

JAK2V617F: you can't have too much.

In this issue of Blood, Tiedt and colleagues use transgenic and retroviral models to demonstrate that the expression level of JAK2V617F plays an important role in determining myeloproliferative disease (MPD) phenotype.